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KMID : 0378019950380020068
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New Medical Journal
1995 Volume.38 No. 2 p.68 ~ p.74
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A Clinical Study on the Hypertensive Effect of Fosinopril
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Abstract
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Background:
A new antihypertensive agent, fosinopril, phosphorus containing angiotensin converting enzyme inhibitor is known to be metabolized and excreted simultaneously by the hepatic and renal systems needs to be studied further on its antihypertensive efficacy and safety in Korean patients.
Method:
Oral fosinopril was administrated to the 30 essential hypertensive patients in doses of 10-30mg once or twice a day. The response of blood pressure was observed every 2 weeks for 12 weeks. Besides the blood pressure lowering effects, subjective symptoms, the change of laboratory findings, adverse reactions of these patients were also observed. Seven patients were excluded from final analysis. The excluded was one because of associated hepatic dysfunction, one pregnancy, one later diagnosed secondary hypertension, and four poor compliance.
Result:
1) After treatment with fosinopril, blood pressures were lowered markedly in 14(61%), moderately in 5(22%), mildly in 3(13%) and there are no change in 1 case(4%). The average blood pressures of 23 subjected to the final analysis were systolic 170±14mmHg and diastolic 107±14mmHg before treatment, which were lowered to 125±16mmHg and 88±9mmHg after 12 weeks tre-atment(p<0.001).
2) The adverse reactions were dry cough in 4 and facial flushing in-2. But they were not serious to quit fosinopril.
3) Heart rate and laboratory findings were not changed throughout the period of treatment.
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KEYWORD
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